Extracurricular organizations currently available to DeSales students (in the grades indicated) include:
- Destination Imagination (2,3 ,4, 5 & 7)
- Future Cities Club (6-8)
- Girls Running Club
- National Junior Honor Society (7 - 8)
- Ski Club (5 - 8)
- Student Council (5 - 8)
- St. Francis Society (7 - 8)
- STREAM Enrichment (Kitchen Chemistry, Lego U, Sprouts etc)
- Robotics (6-8)
- Dance Team (5-8)
- Mass Choir (6-8)
- Girl Scouts
- Boy Scouts